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. Author manuscript; available in PMC: 2021 Jul 3.
Published in final edited form as: Mol Psychiatry. 2020 Jan 3;26(8):3723–3736. doi: 10.1038/s41380-019-0635-6

Fig. 5. Sustaining or eliminating MET signaling in developing forebrain alters the timing of VC critical period plasticity.

Fig. 5.

a. Normal MD-induced critical period plasticity was observed when Metcoe was suppressed by DOX, as MD induced significantly reduced CBI (p < 0.001). b. Metcoe from P14 eliminates critical period plasticity, measured at P32–33 as CBI by single unit recording. c. Extending MET signaling from P14-P40, followed by adding DOX to suppress MET signaling at P40, results in an ectopic period of heightened plasticity (p = 0.0008). d. Continued suppression of Metctg does not change the OD plasticity measured at P42, during which normal critical period is closed. e. Conditional Met knockout in forebrain excitatory neuron eliminates critical period plasticity when measured at P27-P30, during which control littermate exhibits normal plasticity. f. MD-induced OD plasticity in cKO mice exists at an earlier stage (P22–25). Each data point represents a mouse.