Table 3.
Multivariable analysis for event-free survival from EOI and EOC
| Characteristic1 | n | (%) | Event-free Survival from EOI | Event-free Survival from EOC | |||||
|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | p-value | HR | 95% CI | p-value | ||||
| Age at diagnosis | <10 years | 39 | (49) | 1 | -- | 0.278 | 1 | -- | 0.346 |
| ≥10 years | 41 | (51) | 1.69 | 0.65, 4.38 | 1.59 | 0.60, 4.22 | |||
| Initial WBC (/uL) | <50,000 | 57 | (71) | 1 | -- | 0.419 | 1 | -- | 0.384 |
| ≥50,000 | 23 | (29) | 0.65 | 0.23, 1.87 | 0.61 | 0.19, 1.91 | |||
| Cytogenetic classification2 | Neutral | 59 | (74) | 1 | -- | 0.092 | 1 | -- | 0.099 |
| Favorable | 15 | (19) | 0.18 | 0.02, 1.47 | 0.19 | 0.02, 1.48 | |||
| Adverse | 6 | (7) | 2.18 | 0.42, 11.22 | 2.12 | 0.41, 10.90 | |||
| EOI MRD3 | Negative | 57 | (71) | 1 | -- | <0.001 | -- | -- | -- |
| Positive | 23 | (29) | 6.00 | 2.20, 16.37 | -- | -- | -- | ||
| EOI/EOC MRD3 | Neg/Neg | 57 | (71) | -- | -- | -- | 1 | -- | 0.004 |
| Pos/Neg | 13 | (16) | -- | -- | -- | 6.54 | 1.92, 22.25 | ||
| Pos/Pos | 3 | (4) | -- | -- | -- | 9.01 | 1.51, 53.86 | ||
| Pos/Unk. | 7 | (9) | -- | -- | -- | 5.06 | 1.45, 17.70 | ||
1
All candidate predictors in Table 1 tested in stepwise multivariable model with endpoint of OS, see methods. Age, WBC, cytogenetics included as a priori “base” model irrespective of significance.
2
As per AALL08B1 criteria; excludes two patients with unknown cytogenetics.
3
MRD considered positive ≥0.01% at either time-point. HR = hazard ratio, EOI = end of induction, EOC = end of consolidation WBC = white blood cell count