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. Author manuscript; available in PMC: 2021 Sep 2.
Published in final edited form as: Hepatology. 2020 Sep 2;72(3):1085–1101. doi: 10.1002/hep.31096

Figure 5. HCC PDXs retain the genomic expression and mutational profiles of parental tumors.

Figure 5.

A. Principal component analysis (PCA) analysis of RNA-seq data from 7 pairs of parental tumors and PDX samples. T = Tumor, TG = Tumor graft. HS57, HS84, HS119, HS141, HS157 are histologically HCCs. HS127 and HS131 are CCAs.

B. Clustering of samples based on evaluation of highly expressed genes in liver cancer.

C. Whole-exome sequencing in parental tumors and PDX models.

D. Oncoplot of mutations in parental tumors and PDXs. We focused on 35 genes commonly mutated genes in liver cancer based on the TCGA analysis. COSMIC mutations or exome mutations compared to 1000 genomes are shown.