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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: J Neurovirol. 2020 Mar 19;26(3):358–370. doi: 10.1007/s13365-020-00834-3

Table 3.

Association of Plasma and 24-hour PBMC Supernatant Inflammatory Biomarkers with Neurocognitive Domains

Mean (pg/ml)
Concentrations
(±S.D.)		 Subset 1
Multivariate
Model
(p-value)		 Subset 2
Multivariate
Model
(p-value)		 Domains
(univariate significance at
*p <0.05 and **p <0.01 respectively)
Plasma Biomarkers
  CCL8 13.04
(±7.32)		 0.014 1.6 × 10−6 Complex Attention*, Cognitive Flexibility*, Memory*, Psychomotor Speed*, Executive Function*, Processing Speed**
  IL-10 3.03
(±3.68)		 0.230 0.005 Processing Speed**
  IL-23 66.37
(±91.23)		 0.081 0.035 Executive Function*, Processing Speed*
  TIMP1 58470.27
(±51668.42)		 0.010 0.011 Complex Attention**, Cognitive Flexibility*, Psychomotor Speed*, Executive Function*
24-hour PBMC Supernatant Biomarkers
  CCL2 591.92
(±0.57)		 0.026 0.385 Complex Attention**
  IL-17 0.57
(±0.79)		 0.034 0.725 ns

Subset 1: complex attention, cognitive flexibility, memory, reaction time and psychomotor speed neurocognitive domains. Subset 2: executive function and processing speed. Bolded p-values is indicative of significant association observed with multivariate model. ns = no significance. Univariate correlations were not considered if multivariate associations were not significant.