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. Author manuscript; available in PMC: 2020 Nov 28.
Published in final edited form as: Int J Obes (Lond). 2020 May 28;44(7):1596–1606. doi: 10.1038/s41366-020-0603-x

Figure 2. Joint Manhattan plots summarizing GWAS of BMI-associated metabolites in OE and MCDS.

Figure 2.

Genetic associations for 100 shared known (top) or 477 matched (bottom) BMI-associated metabolites were consolidated to plot the best p-value for each SNP (i.e. only the p-value for the best associated metabolite was plotted for each SNP). Genome-wide significance threshold (p < 5 × 10−8) is marked by the orange lines. Genome-wide significant SNPs are plotted in red or blue, for shared known or matched metabolites, respectively. Lead SNPs of the most significant loci (p < 1 × 10−15) are annotated with nearest genes (within 5kb), along with the best associated known metabolites if applicable.