Table 1.

Description of single-gene pharmacogenetic tests.

CPT code	Single-gene pharmacogenetic test	Examples of clinically actionable medicationsa
81225	CYP2C19 (cytochrome P450, family 2, subfamily C, polypeptide 19) (e.g., drug metabolism), gene analysis, common variants (e.g., *2, *3, *4, *8, *17)	Clopidogrel, voriconazole, selective serotonin reuptake inhibitors (i.e., citalopram, escitalopram), tertiary amine tricyclic antidepressants (e.g., amitriptyline)
81226	CYP2D6 (cytochrome P450, family 2, subfamily D, polypeptide 6)(e.g., drug metabolism), gene analysis, common variants (e.g., *2, *3, *4, *5, *6, *9, *10, *17, *19, *29, *35, *41, *1XN, *2XN, *4XN)	Secondary and tertiary amine tricyclic antidepressants (e.g., amitriptyline, nortriptyline), selective serotonin reuptake inhibitors (e.g., paroxetine, fluvoxamine); opioids (e.g., codeine, oxycodone, tramadol), atomoxetine, ondansetron, pitolisant, tamoxifen
81227	CYP2C9 (cytochrome P450, family 2, subfamily C, polypeptide 9) (e.g., drug metabolism), gene analysis, common variants (e.g.,*2, *3,*5, *6)	Phenytoin, siponimid, warfarin
81355	VKORC1 (vitamin K epoxide reductase complex, subunit 1) (e.g., warfarin metabolism), gene analysis, common variant(s) (e.g., −1639G>A, c.173+1000C>T)	Warfarin
81381	HLA class I typing, high resolution (i.e., alleles or allele groups); 1 allele or allele group (e.g., B*57:01P), each	Abacavir, allopurinol, carbamazepine, oxcarbazepine, phenytoin
81350	UGT1A1 (UDP glucuronosyltransferase 1 family, polypeptide A1) (e.g., irinotecan metabolism), gene analysis, common variants (e.g., *28, *36, *37)	Atazanavir, irinotecan

CPT Current Procedural Terminology.

^aClinically actionable, as defined by Clinical Pharmacogenetics Implementation Consortium (CPIC) Level A designation.