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. 2020 Aug 20;182(4):812–827.e19. doi: 10.1016/j.cell.2020.06.043

Figure 5.

Figure 5

Clinical Status and D614G Associations Based on 999 Subjects with COVID-19 and Linked Sequence and Clinical Data Were Sampled in Sheffield, England

(A) G614 was associated with a lower cycle threshold (Ct) required for detection; lower values are indicative of higher viral loads. The PCR method was changed partway through April 2020 because of shortages of nucleic acid extraction kits (Fomsgaard and Rosenstierne, 2020). The Ct levels for the two PCR methods (nucleic acid extraction versus simple heat inactivation) differ, and so we used a GLM to evaluate the statistical effect of D614G across methods.

(B) D614G status was not statistically associated with hospitalization status (outpatient [OP], inpatient [IP], or ICU) as a marker of disease severity, but age was highly correlated. The number of counts in each category is noted in the top right corner of each graph. See the main text and STAR Methods for statistical details.