Table 1.
Literature review of tuberculosis with ruxolitinib treatment in patients with primary myelofibrosis.
| Year/reference | Country | Age /sex | Culture | Diagnosis (abnormality) | Timing of infection after the start of ruxolitinib | IGRA before ruxolitinib | IGRA after diagnosis of TB | Treatment for LTBI | Other risk of tuberculosis | Ruxolitinib therapy after diagnosis of infection | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Branco (2016) [5] | Born in Algeria but living in France | 78/F | Cervical lymph node | Disseminated (cervical lymph node, T4–T5 spinal disc) | 1.5 years | NA | Positive | None | Diabetes | Continued | Alive |
| Shamil (2015) [6] | UK | 78/F | Cervical lymph node | Disseminated (cervical lymph node, lung) | Unspecified | NA | NA | None | None | Discontinued | Alive |
| Keizer (2015) [7] | Netherland | 72/M | N/A | Disseminated(N/A) | 5 months | Not performed | NA | N/A | N/A | Discontinued | dead |
| Keizer (2015) [7] | Netherland | 68/M | N/A | Pulmonary | 4 weeks | Not performed | NA | N/A | N/A | Discontinued | dead |
| Chen (2015) [9] | Taiwan | 82/M | Sputum | Pulmonary | 2 months | NA | NA | None | PSL 10 mg | Discontinued | Alive |
| Palandri (2015) [10] | Italy | 65/F | Lymph node | Extrapulmonary (subaxillary lymph nodes) | 4 months | Not performed | Negative | None | none | Discontinued | Alive |
| Hopman (2014) [11] | Emigrated from Vietnam to the United States | 62/M | BALF, blood | Disseminated (lung, lymph node) | 7 weeks | NA | NA | none | none | Discontinued | Alive |
| Colomba (2012) [12] | Italy | Unspecified/M | Inguinal lymph node, sputum | Disseminated (inguinal lymph node, lung) | 2 months | NA | Positive | None | none | Unspecified | Unspecified |
| Panda (2016) [13] | India | 35/M | Right psoas abscess | Disseminated (psoas muscle, para-aortic lymph node, lung) | 2 years | NA | NA | None | hydroxyurea | 6 weeks continued, discontinued | Alive |
| Abidi (2016) [14] | India | 69/M | Cervical lymph node | Disseminated (lung, cervical lymph node) | 3 weeks | NA | Positive | None | None | Discontinued | Alive |
| Tsukamoto (2017) [8] | Japan | 73/M | Sputum, gastric lavage fluid, blood, and urine | Disseminated (lung) | 6 months | NA | Positive | None | PSL 5 mg | Discontinued | dead |
| Lescuyer et al. (2019) [15] | France | 73/M | Cerebral biopsy | Disseminated (lung, brain) | 5 months | NA | Positive | None | None | Discontinued | dead |
| Current | Japan | 80/M | Sputum, skin abscess | Disseminated (skin abscess, lung, spine) | 10 months | Not performed | Positive | None | PSL 5 mg | 4 months continued, discontinued | dead |
NA: not available; there was no relevant information in the manuscript.