Fig. 5.
Inverse correlations of DNA methylation with glioma stem-cell marker gene expression. A, Comparative analysis of the TCGA-LGG data set showing significantly higher median levels of DNA methylation in CD44, NES, and PROM1 but lower in SOX2 in IDH-mutant (mIDH) glioma compared with IDH-wildtype (IDH) glioma. B, Pearson correlations showing inverse correlations between DNA methylation and gene expression in IDH-mutant glioma (circles), as indicated by p and R2 values, and also in IDH-wildtype glioma (triangles).