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. 2020 Jul 1;13(10):100819. doi: 10.1016/j.tranon.2020.100819

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 5 — Inverse correlations of DNA methylation with glioma stem-cell marker gene expression. A, Comparative analysis of the TCGA-LGG data set showing significantly higher median levels of DNA methylation in CD44, NES, and PROM1 but lower in SOX2 in IDH-mutant (mIDH) glioma compared with IDH-wildtype (IDH) glioma. B, Pearson correlations showing inverse correlations between DNA methylation and gene expression in IDH-mutant glioma (circles), as indicated by p and R² values, and also in IDH-wildtype glioma (triangles).