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. 2020 Jul 1;13(10):100819. doi: 10.1016/j.tranon.2020.100819

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 6 — Differential epigenetic modifications between CD24 and NES in IDH1^R132H-heterozygous cells. A, Bisulfite sequencing results showing lower levels of CpG methylation (filled circles) in CD24 but higher levels in NES in IDH1^R132H-heterozygous cells than in IDH1^R132H-hemizygous cells. B, Quantitative analysis of the bisulfite sequencing results. C, Chromatin immunoprecipitation of BT142 spheroids revealed an opposing trend of H3K27me3 (n = 9) between CD24 and NES, presented in a log2 ratio of IDH1^R132H-heterozygous cells over IDH1^R132H-hemizygous cells.