Fig. 2.

Comparison of human sHSP ACD sequences. All sequences shown except HSPB8 have experimentally determined atomic-level ACD structures (Janowska et al. 2019). The sequences that compose each of the six β-strands are highlighted in dashed boxes, with the strands that create the bottom sheet in gray and the top sheet in magenta. Residues whose sidechains create the ACD grooves are denoted in blue symbols for dimer interface (#, end of groove; %, floor of groove) and orange symbols for the edge groove (&, end of groove; +, floor of groove). CTR I/V-X/I/V motifs are denoted with underlining