Fig. 6.

Refolding process of a denatured I27 domain upon relaxation of the applied force, under different experimental conditions (Nunes et al. 2015). a In the absence of chaperones, the unfolded domain mostly misfolds. b In the presence of DnaJ, the I27 domain misfolds less and transits into its native state more often, while the probability of remaining unfolded does not change. c In the presence of DnaJ and DnaK (1:2 M ratio), the I27 domain folds into its native state most of the time, or alternatively remains unfolded. Misfolding is almost abolished. Reprinted with permission from Springer Nature Customer Service Centre GmbH: Springer Nature, Nature Communications (Nunes et al. 2015), Copyright 2015