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SFS and GERP++ Distributions Reflect Selection on Codon Usage
(A) Site frequency spectra of synonymous variants that result in optimal-to-nonoptimal (O → NO), neutral, and nonoptimal-to-optimal codon (NO → O) changes (left panel) and matched intronic variants (right panel).
(B) Distribution of GERP++ scores for the reference alleles of the variants included in (A).
