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. 2019 Nov 1;10(6):1106–1121. doi: 10.1016/j.apsb.2019.10.011

Figure 3.

Figure 3

In vitro properties of nanoparticles. Viabilities of A549 cells treated with PPPN, PSPN, and PSPPN for 24 (A) or 48 h (B). (C) Stability of nanoparticles during storage as measured by the particle size and zeta potential for 4 weeks. (D) In vitro release of Pt–CUR from Pt–CUR@PSPPN incubated with or without 10 mmol/L DTT at pH 7.4 or 5.5. (E) In vitro drug release profiles of Pt–CUR@PPPN, Pt–CUR@PSPN and Pt–CUR@PSPPN kept at pH 5.5 with 10 mmol/L DTT. The uptake of free Pt–CUR and Pt–CUR@PSPPN by A549 cells. (F) Fluorescence microscope images of cells incubated for 4 h. PBS was used as a control. (G) Mean fluorescence intensity in cells at 1, 4 and 8 h after incubation. Data are expressed as mean ± SD (n = 3). *P < 0.05, **P < 0.01.