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. 2019 Nov 1;10(6):1106–1121. doi: 10.1016/j.apsb.2019.10.011

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© 2020 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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In vivo anti-metastasis effect. (A) H&E staining and immunohistochemical analysis including CD31, VEGF and MMP2 of A549 xenograft tumors. Cell nucleus was colored by DAPI with blue fluorescence and antibody signals were counterstained with red or green fluorescence. (B) Image of excised lungs in metastasis model at the end of the experiment. Mice were given tail vein injection of A549 cells and treated with PBS, free CDDP, free CUR, combo of free drugs, free Pt–CUR as well as Pt–CUR@PSPPN on day 2, 4, 6 and 8. (C) Quantitative analysis of the metastatic lung nodules. Data are expressed as mean ± SD (n = 5). *P < 0.05, **P < 0.01.