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The activation of cyclic peptide C25 on CD8+ T cells was determined in vitro. (A) Cyclic peptide C25 has the function of stimulating secretion of IFN-γ by human PBMCs. Effects of cyclic peptide C25 on the percentage of (B and C) CD8+ IFN-γ+ T cells and (D and E) CD4+ IFN-γ+ T cells. Data are expressed as the mean ± SD (n = 3) and statistical significance between groups was determined by Student's t test: **P < 0.01; ns, not significant.
