Figure 6.

Effect of cyclic peptide C25 on CT26 tumor cells after depletion CD8⁺ T cells in mice. BALB/c mice were intraperitoneal injected with 250 μg of CD8-depleting antibody the day before CT26 tumor inoculation and every four days thereafter, 200 μg Rat Ig as control. Cyclic peptide C25 (2 mg/kg/day) was treated for 14 days when the tumor grew to 40–80 mm³. The (A) tumor volumes and (B) tumor sizes after CD8⁺ T cell deletion. Data are expressed as the mean ± SD (n = 5) and statistical significance between groups was determined by Student's t test: ∗P < 0.05, ***P < 0.001; ns, not significant.