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. 2020 Jun 26;11:725. doi: 10.3389/fphys.2020.00725

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Copyright © 2020 McArdle, Schreuder, Moritz, Denton and Singh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Postnatal maturation of kidney function in healthy individuals with two kidneys (solid line) and maturation of kidney function in children with a congenital SFK (dotted line). (a) The phase after birth when GFR increases. This phase is likely enhanced in children who lose a kidney early in life. (b) GFR reaches its peak and is maintained within normal range for most of life in the absence of a “second hit” such as obesity, hypertension, and diabetes. This phase is likely to be shorter in children with SFK, possibly due to enhanced compensatory adaptations increasing the risk of kidney dysfunction. (c) Age-related decline in GFR in kidneys. This phase may be accelerated in individuals with SFK with kidney dysfunction and in some cases may result in kidney failure.