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. 2020 Jun 26;13:109. doi: 10.3389/fnmol.2020.00109

Figure 1.

Figure 1

Cosyntropin (CoSyn) increases serum corticosterone levels and decreases weight gain. (A) Experimental design for early inflammatory response. (B) Experimental design for behavioral outcomes. (C) Serum corticosterone levels were increased at day post-injury (DPI) 3 in both sham- and traumatic brain injury (TBI)-treated animals. Sham-saline (n = 4), sham-CoSyn (n = 4), TBI-saline (n = 7), TBI-CoSyn (n = 8). (D) All experimental groups exhibited post-surgery weight loss. (D) Mice treated with CoSyn did not show post-surgical increased weight loss but did demonstrate sustained levels of weight loss at DPI 7 compared to saline-treated mice. Sham-saline (n = 10), sham-CoSyn (n = 11), TBI-saline (n = 14), TBI-CoSyn (n = 14). Significance was determined using two-way ANOVA with Tukey post hoc testing (C) and repeated-measures ANOVA (D). Graphs represent means and error bars show SEM. *Main effect of treatment, p < 0.05, ‡p < 0.001.