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. 2020 Jun 26;13:109. doi: 10.3389/fnmol.2020.00109

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Copyright © 2020 Siebold, Krueger, Abdala, Figueroa, Bartnik-Olson, Holshouser, Wilson and Ashwal.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Injury-induced anxiety-like behavior and increased memory with treatment. (A) TBI mice exhibit reduced time in the center compare to sham animals. No effect of treatment in either group was seen. (B) No difference between the average speed at DPI 3 between any treatment or injury group. (C) CoSyn increased time-spent exploring novel objects during novel object recognition (NOR) testing as indicated by increased discrimination index. Sham-saline (n = 10), sham-CoSyn (n = 11), TBI-saline (n = 14), TBI-CoSyn (n = 14). Significance was determined using two-way ANOVA with Tukey post hoc testing. Graphs represent means and error bars show SEM, *p < 0.05.