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. 2020 Jun 26;13:109. doi: 10.3389/fnmol.2020.00109

Figure 6.

Figure 6

CoSyn induces modest improvements in early Morris water maze (MWM) performance post-TBI. (A) Mean duration to find platform across training days. All groups improved over consecutive learning days. TBI mice treated with saline spent more time finding the platform compared to TBI mice treated with CoSyn and both sham groups on training days 1 and 2. Training day comparisons with p < 0.05: Sham groups (φ), TBI groups (†), Saline groups (#), CoSyn groups (π). (B) A probe test was performed following the final training day. Both TBI groups had fewer platform crossings compared to sham groups. There was no significant difference between treated and untreated groups. (C) No differences were detected in swim speed between experimental groups during the probe trial. Sham-saline (n = 10), sham-CoSyn (n = 11), TBI-saline (n = 12), TBI-CoSyn (n = 12). Significance was determined using two-way ANOVA (B,C) and repeated-measures ANOVA (A) with Tukey post hoc testing. Graphs represent means and error bars show SEM.