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. 2020 Jun 26;11:951. doi: 10.3389/fphar.2020.00951

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Copyright © 2020 Chen, Zhang, Ma, Huang, Li, Lou, Li, Tu and Gao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sit and 3MA ameliorate multiterritory perforator flap survival. (A) Digital photographs of flap survival/necrosis area on the 3^rd and 7^th PODs in the control, Sit, and Sit+3MA groups. (B) The percentages of survival area in each group. (C) LDBF imaging showing vascular flow and blood supply in a perforator flap on the 0, 3^rd, and 7^th PODs in the control, Sit, and Sit+3MA groups. (D) Histogram representing the quantified signal intensity on the 0, 3^rd, and 7^th PODs. (E) Flap angiograms on the 7^th PODs and the vasculature was in a mass in the necrosis area. **p < 0.01, vs control group; ^@p < 0.05 and ^@@ < 0.01, vs Sit group. Data are expressed as mean ± standard error, n = 6 per group.