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. 2020 Jun 26;11:951. doi: 10.3389/fphar.2020.00951

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Copyright © 2020 Chen, Zhang, Ma, Huang, Li, Lou, Li, Tu and Gao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sit regulates the PI3K/Akt signaling pathway to attenuate apoptosis. (A) Expressions of PI3K, p-PI3K, Akt, and p-Akt in the flap using western blotting in the control, Sit, and Sit+3MA groups. Gels have been run under the same experimental conditions and cropped blots are used here. (B) Histogram representing quantification and analysis of optical density values of PI3K, p-PI3K, Akt, and p-Akt. *p < 0.05 and **p < 0.01, vs control group; ^@@p < 0.01, vs Sit group. Data are presented as mean ± standard error, n = 6 per group.