Table 2.
Association between candidate SNPs and efficacy of radiotherapy.
| Gene | SNPs | Genotype | CR + PR | SD + PD | OR (95% CI) | p | |
|---|---|---|---|---|---|---|---|
| XRCC1 | rs25487 | CC | 130 | 111 | Reference | Reference | |
| CT | 81 | 98 | 0.706 (0.479–1.041) | 0.078 | |||
| TT | 23 | 43 | 0.457 (0.259–0.804) | 0.006 | |||
| CT + TT | 104 | 141 | 0.630 (0.440–0.901) | 0.011 | |||
| rs25489 | CC | 190 | 203 | Reference | Reference | ||
| CT | 42 | 47 | 0.955 (0.602–1.514) | 0.844 | |||
| TT | 2 | 2 | 1.068 (0.149–7.661) | 0.947 | |||
| CT + TT | 44 | 49 | 0.959 (0.610–1.509) | 0.858 | |||
| rs1799782 | GG | 128 | 121 | Reference | Reference | ||
| AG | 84 | 97 | 0.819 (0.558–1.201) | 0.306 | |||
| AA | 22 | 34 | 0.612 (0.339–1.105) | 0.101 | |||
| AG + AA | 106 | 131 | 0.765 (0.535–1.093) | 0.141 | |||
| rs3213245 | AA | 182 | 181 | Reference | Reference | ||
| AG | 53 | 66 | 0.799 (0.527–1.211) | 0.289 | |||
| GG | 3 | 5 | 0.597 (0.141–2.534) | 0.479 | |||
| AG + GG | 56 | 71 | 0.784 (0.523–1.178) | 0.241 | |||
| XRCC2 | rs3218544 | GG | 82 | 78 | Reference | Reference | |
| AG | 114 | 133 | 0.815 (0.547–1.214) | 0.315 | |||
| AA | 38 | 41 | 0.882 (0.514–1.512) | 0.647 | |||
| AG + AA | 152 | 174 | 0.831 (0.569–1.214) | 0.338 | |||
| rs3218385 | AA | 172 | 172 | Reference | Reference | ||
| AC | 53 | 73 | 0.726 (0.481–1.096) | 0.127 | |||
| CC | 9 | 7 | 1.286 (0.468–3.530) | 0.625 | |||
| AC + CC | 62 | 80 | 0.775 (0.523–1.148) | 0.203 | |||
| rs3218556 | GG | 166 | 149 | Reference | Reference | ||
| AG | 57 | 77 | 0.664 (0.442–0.999) | 0.049 | |||
| AA | 11 | 26 | 0.380 (0.181–0.795) | 0.008 | |||
| AG + AA | 68 | 103 | 0.593 (0.406–0.865) | 0.006 | |||
| MSH2 | rs2303424 | GG | 86 | 102 | Reference | Reference | |
| AG | 117 | 129 | 1.076 (0.735–1.574) | 0.707 | |||
| AA | 31 | 20 | 1.599 (0.868–2.945) | 0.131 | |||
| AG + AA | 148 | 149 | 1.178 (0.817–1.699) | 0.380 | |||
| rs2303425 | TT | 147 | 166 | Reference | Reference | ||
| CT | 72 | 62 | 1.311 (0.874–1.968) | 0.190 | |||
| CC | 15 | 24 | 0.706 (0.357–1.396) | 0.315 | |||
| CT + CC | 87 | 86 | 1.142 (0.788–1.657) | 0.483 | |||
| XPD | rs238419 | CC | 79 | 95 | Reference | Reference | |
| CT | 101 | 110 | 1.104 (0.738–1.651) | 0.629 | |||
| TT | 54 | 47 | 1.382 (0.845–2.259) | 0.197 | |||
| CT + TT | 155 | 157 | 1.187 (0.818–1.722) | 0.366 | |||
| rs13181 | TT | 176 | 209 | Reference | Reference | ||
| GT | 56 | 40 | 1.663 (1.057–2.614) | 0.027 | |||
| GG | 2 | 3 | 0.792 (0.131–4.791) | 0.799 | |||
| GT + GG | 58 | 43 | 1.602 (1.029–2.493) | 0.036 | |||
The p values in bold represent a statistically significant association. All data are adjusted for age, gender, smoking history, cancer histology, family history, and treatment with chemotherapy.