Table 3.
Association between candidate SNPs and radiation-induced toxic reactions.
| Gene | SNPs | Genotype | Low toxic reactions | High toxic reactions | OR (95% CI) | p |
|---|---|---|---|---|---|---|
| XRCC1 | rs25487 | CC | 188 | 74 | Reference | Reference |
| CT | 114 | 69 | 0.650 (0.435–0.972) | 0.035 | ||
| TT | 23 | 18 | 0.503 (0.257–0.986) | 0.043 | ||
| CT + TT | 137 | 87 | 0.620 (0.424–0.907) | 0.013 | ||
| rs25489 | CC | 257 | 122 | Reference | Reference | |
| CT | 65 | 38 | 0.812 (0.515–1.279) | 0.369 | ||
| TT | 3 | 1 | 0.424 (0.147–13.83) | 0.759 | ||
| CT + TT | 68 | 39 | 0.828 (0.528–1.297) | 0.409 | ||
| rs1799782 | GG | 175 | 91 | Reference | Reference | |
| AG | 117 | 58 | 1.049 (0.700–1.571) | 0.817 | ||
| AA | 33 | 12 | 1.430 (0.705–2.902) | 0.320 | ||
| AG + AA | 150 | 70 | 1.114 (0.762–1.630) | 0.577 | ||
| rs3213245 | AA | 248 | 117 | Reference | Reference | |
| AG | 74 | 43 | 0.812 (0.525–1.255) | 0.348 | ||
| GG | 3 | 1 | 1.415 (0.146–13.75) | 0.764 | ||
| AG + GG | 77 | 44 | 0.826 (0.537–1.270) | 0.383 | ||
| XRCC2 | rs3218544 | GG | 117 | 49 | Reference | Reference |
| AG | 162 | 83 | 0.817 (0.534–1.251) | 0.353 | ||
| AA | 46 | 28 | 0.688 (0.387–1.224) | 0.202 | ||
| AG + AA | 208 | 111 | 0.785 (0.523–1.177) | 0.241 | ||
| rs3218385 | AA | 235 | 109 | Reference | Reference | |
| AC | 78 | 47 | 0.770 (0.502–1.180) | 0.229 | ||
| CC | 12 | 5 | 1.113 (0.383–3.238) | 0.844 | ||
| AC + CC | 90 | 52 | 0.803 (0.533–1.210) | 0.293 | ||
| rs3218556 | GG | 238 | 96 | Reference | Reference | |
| AG | 78 | 52 | 0.605 (0.396–0.924) | 0.019 | ||
| AA | 9 | 13 | 0.279 (0.116–0.675) | 0.003 | ||
| AG + AA | 87 | 65 | 0.540 (0.362–0.805) | 0.002 | ||
| MSH2 | rs2303424 | GG | 123 | 52 | Reference | Reference |
| AG | 156 | 82 | 0.804 (0.528–1.224) | 0.309 | ||
| AA | 46 | 27 | 0.720 (0.405–1.280) | 0.263 | ||
| AG + AA | 202 | 109 | 0.783 (0.526–1.168) | 0.230 | ||
| rs2303425 | TT | 204 | 106 | Reference | Reference | |
| CT | 104 | 45 | 1.201 (0.788–1.830) | 0.394 | ||
| CC | 17 | 10 | 0.883 (0.391–1.997) | 0.765 | ||
| CT + CC | 121 | 55 | 1.143 (0.769–1.698) | 0.508 | ||
| XPD | rs238419 | CC | 102 | 43 | Reference | Reference |
| CT | 149 | 77 | 0.816 (0.520–1.280) | 0.375 | ||
| TT | 74 | 41 | 0.761 (0.451–1.283) | 0.304 | ||
| CT + TT | 223 | 118 | 0.797 (0.523–1.213) | 0.289 | ||
| rs13181 | TT | 235 | 130 | Reference | Reference | |
| GT | 82 | 27 | 1.680 (1.035–2.728) | 0.035 | ||
| GG | 8 | 4 | 1.106 (0.327–3.745) | 0.871 | ||
| GT + GG | 90 | 31 | 1.624 (1.025–2.547) | 0.038 |
The p values in bold indicate a statistically significant association. All data are adjusted for age, gender, smoking history, cancer histology, family history, and treatment with chemotherapy.