Table 3. Comparison between demographic, severity scoring, and baseline perfusion variables in target reachers and non-reachers.
| Variable | Reacher | Non-reacher | P |
|---|---|---|---|
| N | 18 | 24 | |
| Age (years) | 63 [47–74] | 64 [43–75] | 0.9 |
| Female (%) | 10 | 14 | 0.8 |
| Surgical foci (%) | 44 | 71 | 0.08 |
| SOFA | 9 [6–12] | 11 [7–14] | 0.19 |
| APACHE-II | 24 [15–30] | 23 [15–32] | 0.7 |
| Charlson | 1 [0–3] | 1 [0–5] | 0.5 |
| Pre protocol fluid (mL) | 2,375 [1,000–3,138] | 2,025 [1,050–3,000] | 0.8 |
| Time to antibiotics (min) | 60 [30–98] | 60 [30–60] | 0.3 |
| CRT (seconds) | 4 [3–5] | 6 [3.1–8.7] | 0.07 |
| Lactate (mol/L) | 3 [2.5–4.3] | 4.6 [3–8.7] | 0.01 |
| Norepinephrine dose (mcg/kg/min) | 0.27 [0.11–0.42] | 0.3 [0.2–0.5] | 0.9 |
| ScvO2 (%) | 68 [64–74] | 75 [61–82] | 0.3 |
| Delta pCO2(v-a) (mmHg) | 8 [6–12] | 7 [3–11] | 0.3 |
| Ca–vO2 (ΔPCO2/Ca–vO2) | 2.3 [1.1–2.8] | 1.3 [0.9–2.5] | 0.3 |
| LPR | 7.4 [4–13.8] | 9.5 [5.3–14] | 0.4 |
| NIRS (%) | 79 [73–83] | 75 [66–82] | 0.3 |
| PDR-ICG (%) | 12 [9–20] | 15 [11–19] | 0.6 |
| MFI | 2.4 [1.9–3] | 2.5 [1–2.6] | 0.6 |
APACHE II, Acute Physiology and Chronic Health Evaluation II; SOFA, Sequential Organ Failure Assessment score; MAP, mean arterial pressure; DBP, diastolic blood pressure; CVP, central venous pressure; CRT, Capillary refill time; ScvO2, central venous oxygen saturation delta pCO2(v-a), difference between central venous carbon dioxide pressure and arterial carbon dioxide pressure; ΔPCO2/Ca–vO2, ratio between veno–arterial PCO2 difference and Ca–vO2; LPR, lactate/pyruvate ratio; NIRS, near-infrared spectophotoscopy; PDR-ICG, liver blood flow by Indocyanine green plasma disappearance rate MFI, Mean flow index