Table S1. Clinical characteristics of the studied subjects.
| Characteristics | Discovery cohort | Validation cohort | Combined cohort | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| CAD (n=30) | Control (n=30) | P | CAD (n=300) | Control (n=179) | P | CAD (n=330) | Control (n=209) | P | |||
| Male, n (%) | 29 (98.7) | 27 (90.0) | 0.605c | 208 (69.3) | 123 (68.7) | 0.887c | 237 (71.8) | 150 (71.8) | 0.990c | ||
| Age, years | 58.2±3.4 | 57.8±4.0 | 0.089a | 61.3±11.3 | 62.5±9.9 | 0.025a | 60.9±10.9 | 61.9±9.4 | 0.308a | ||
| BMI, kg/m2 | 24.5±2.9 | 24.2±2.1 | 0.620a | 25.1±3.4 | 24.3±1.9 | <0.0001a | 25.1±3.6 | 24.3±1.9 | 0.006a | ||
| Smoking, n (%) | 24 (80.0) | 16 (53.3) | 0.028c | 165 (55.0) | 43 (24.0) | <0.0001c | 189 (57.3) | 59 (28.2) | <0.0001c | ||
| Alcoholism, n (%) | 9 (30.0) | 6 (20.0) | 0.371c | 74 (24.7) | 28 (15.6) | 0.020c | 83 (25.2) | 34 (16.3) | 0.015c | ||
| Hypertension, n (%) | 14 (46.7) | 9 (30.0) | 0.184c | 191 (63.7) | 57 (31.8) | <0.0001c | 206 (62.4) | 66 (31.6) | <0.0001c | ||
| Hyperlipidemia, n (%) | 7 (23.3) | 5 (16.7) | 0.519c | 62 (20.7) | 20 (11.2) | 0.008c | 68 (20.6) | 25 (12.0) | 0.010c | ||
| T2DM, n (%) | 8 (26.7) | 6 (20.0) | 0.542c | 85 (28.3) | 26 (14.5) | 0.001c | 92 (27.9) | 32 (15.3) | 0.001c | ||
| FPG, mmol/L | 7.14 (5.99, 9.16) | 5.44±0.39 | <0.0001b | 6.32 (5.39, 8.85) | 5.19±0.57 | <0.0001b | 6.39 (5.42, 8.86) | 5.24 (4.98, 5.57) | <0.0001b | ||
| TC, mmol/L | 4.08±1.11 | 4.42±0.46 | 0.001a | 4.13 (3.37, 4.74) | 4.36±0.53 | <0.0001b | 4.12 (3.37, 4.74) | 4.49 (4.01, 4.80) | <0.0001b | ||
| TG, mmol/L | 1.75 (1.02, 2.25) | 1.04±0.37 | 0.005b | 1.46 (1.07, 2.16) | 1.13±0.30 | <0.0001b | 1.47 (1.07, 1.18) | 1.13 (0.85, 1.39) | <0.0001b | ||
| HDL-C, mmol/L | 0.97±0.28 | 1.58±0.34 | <0.0001a | 1.00 (0.86, 1.19) | 1.53±0.33 | <0.0001b | 0.99 (0.85, 1.18) | 1.47 (1.28, 1.75) | <0.0001b | ||
| LDL-C, mmol/L | 2.41±0.79 | 2.75±0.41 | 0.010a | 2.40 (1.86, 2.88) | 2.70±0.51 | <0.0001b | 2.40 (1.86, 2.87) | 2.78 (2.42, 3.09) | <0.0001b | ||
| WBC, 109/L | 8.97±2.99 | 6.52±1.86 | <0.0001a | 7.46 (5.83, 9.57) | 6.14±1.54 | <0.0001b | 7.63 (5.98, 9.88) | 6.1 (5.11, 7.00) | <0.0001b | ||
| NEU, 109/L | 6.43±3.19 | 3.75±1.58 | <0.0001a | 5.14 (3.80, 8.20) | 3.46±1.16 | <0.0001b | 5.01 (3.72, 7.38) | 3.35 (2.63, 4.00) | <0.0001b | ||
| LYM, 109/L | 1.75±0.62 | 2.10±0.75 | 0.054a | 1.53 (1.17, 2.17) | 2.01±0.62 | <0.0001b | 1.50 (1.14, 2.01) | 1.99 (1.55, 2.42) | <0.0001b | ||
| MON, 109/L | 0.64±0.27 | 0.49±0.18 | 0.015a | 0.52 (0.42, 0.70) | 0.46±0.14 | 0.001b | 0.52 (0.42, 0.67) | 0.46 (0.36, 0.59) | <0.0001b | ||
| PLT, 109/L | 230±90 | 185±40 | 0.043a | 199 (156, 233) | 182±50 | 0.040b | 191.60 (158.3, 234.2) | 177 (149, 220) | 0.003b | ||
| CRP, mg/L | 4.22 (1.06, 12.50) | – | – | 2.74 (0.95, 7.75) | – | – | 2.98 (0.98, 8.33) | – | – | ||
| NT-proBNP, pg/mL | 372 (147, 565) | – | – | 371 (105, 1,107) | – | – | 372.3 (107.25, 1,070.5) | – | – | ||
| cTnT, ng/mL | 3.47 (0.26, 20.96) | – | – | 0.91 (0.012, 11.88) | – | – | 1.00 (0.031, 13.00) | – | – | ||
| Gensini scores | 48.0 (38.4, 79.5) | – | – | 44.5 (22, 73.4) | – | – | 45.25 (22.75, 74.625) | – | – | ||
| LVEF, % | 63 (60.75, 63.25) | – | – | 63 (60, 64) | – | – | 63 (60, 64) | – | – | ||
| History of stains use, n (%) | 14 (46.7) | – | – | 147 (52.3) | – | – | 161 (51.8) | – | – | ||
| Last cardiovascular event time, day | 2 (1, 2) | – | – | 1 (1, 2) | – | – | 1 (1, 2) | – | – | ||
For continuous variables, normally distributed data were expressed as mean ± standard deviation (SD), while skewed data were described as median (interquartile range). For categorical, data were expressed as frequency counts. a, Student’s t test; b, Mann-Whitney U test; c, χ2 test. CAD, coronary artery disease; BMI, body mass index; T2DM, type 2 diabetes mellitus; FPG, fasting plasma glucose; TC, total cholesterol; TG, triglyceride; HDL-c, high-density lipoprotein cholesterol; LDL-c, low-density lipoprotein cholesterol; WBC, white blood cell counts; NEU, neutrophil counts; LYM, lymphocyte counts; MON, monocyte counts; PLT, platelet counts; CRP, c-reaction protein; NT-proBNP, N-terminal pro-brain natriuretic peptide; cTnT, cardiac troponin T; LVEF, left ventricular ejection fraction.