Table 3. Descriptive statistics for derived traits between the EC and control cohort.
| Derived traits | Description | Control, median (IQR) | EC, median (IQR) | ORa | Pa |
|---|---|---|---|---|---|
| Percentage of galactosylation | |||||
| G0n | Proportion of agalactosylated structures in neutral glycans | 31.62 (26.40–37.61) | 38.61 (33.25–43.06) | 1.15 (1.09–1.22) | <0.0001* |
| G1n | Proportion of monogalactosylated structures in neutral glycans | 44.02 (42.31–45.27) | 43.02 (40.95–45.14) | 0.87 (0.78–0.98) | 0.019* |
| G2n | Proportion of digalactosylated structures in neutral glycans | 23.70 (18.32–29.25) | 18.63 (15.43–21.96) | 0.83 (0.77–0.89) | <0.0001* |
| Percentage of sialylation | |||||
| S total | Proportion of sialylated structures in total IgG glycans | 11.68 (8.78–13.77) | 9.26 (7.42–11.40) | 0.85 (0.78–0.94) | 0.002* |
| S1 total | Proportion of monosialylated structures in total IgG glycans | 10.21 (7.72–11.94) | 8.06 (6.48–9.75) | 0.82 (0.73–0.92) | 0.001* |
| S2 total | Proportion of disialylated structures in total IgG glycans | 1.21 (0.69–1.87) | 1.03 (0.77–1.47) | 0.87 (0.60–1.26) | 0.45 |
| Percentage of fucosylation and bisecting GlcNAc | |||||
| F total | Proportion of fucosylated glycans in total IgG glycans | 95.51 (94.51–96.45) | 96.41 (95.63–97.03) | 1.52 (1.20–1.93) | 0.001* |
| Bisecting GlcNAc | Proportion of structures with GlcNAc in total IgG glycans | 16.91 (15.53–18.40) | 18.33 (16.09–20.95) | 1.17 (1.05–1.29) | 0.003* |
| Percentage of fucosylation +/− bisecting GlcNAc | |||||
| Fn | The percentage of fucosylated (without bisecting GlcNAc) structures in total neutral IgG glycans | 79.61 (77.86–81.38) | 79.03 (75.92–81.33) | 0.94 (0.87–1.02) | 0.141 |
| FBn | Proportion of fucosylated (with bisecting GlcNAc) structures in total neutral IgG glycans | 16.93 (15.69–18.83) | 18.30 (16.52–21.18) | 1.19 (1.08–1.32) | 0.001* |
| FBn/Fn | Ratio of fucosylated structures with and without bisecting GlcNAc | 21.28 (19.35–24.45) | 23.13 (20.23–27.69) | 1.10 (1.04–1.17) | 0.002* |
a, OR and P values were adjusted by age and BMI using bivariate logistic regression analysis. P values <0.05 are marked with “*”. B, bisecting GlcNAc; F, core fucose; G, galactose; S, sialic acid; OR, odds ratio. See Table 2 for the definitions of derived traits.