Table 1. Cancer Diagnosis in Male BRCA1/2 Pathogenic Variant (PV) Carriers Within CIMBA Data Set and Odds Ratios (ORs) in Predicting BRCA2 PV Carrier Status.
| No. (%) | Adjusted OR (95% CI)a | P value | |||
|---|---|---|---|---|---|
| Total (N = 6902) | BRCA1 (n = 3651) | BRCA2 (n = 3251) | |||
| Unaffected | 5526 (80.1) | 3197 (87.6) | 2329 (71.6) | 1.00 [Reference] | |
| Affected | 1376 (19.9) | 454 (12.4) | 922 (28.4) | 3.23 (2.81-3.70) | <.001 |
| Cases with 1 cancer diagnosis | 1144 (83.1) | 416 (91.6) | 728 (79.0) | 2.77 (2.40-3.20) | <.001 |
| Breast cancer | 380 (33.2) | 50 (12.0) | 330 (45.3) | ||
| Prostate cancer | 273 (23.9) | 83 (20.0) | 190 (26.1) | ||
| Cancer other than breast and prostate | 491 (42.9) | 283 (68.0) | 208 (28.6) | ||
| Cases with 2 cancer diagnoses | 206 (15.0) | 36 (8.0) | 170 (18.4) | 7.97 (5.47-11.60) | <.001 |
| Bilateral breast cancer | 24 (11.7) | 0 | 24 (14.1) | ||
| Breast and prostate cancer | 53 (25.7) | 4 (11.1) | 49 (28.8) | ||
| Breast cancer and cancer other than breast and prostate | 59 (28.6) | 8 (22.2) | 51 (30.0) | ||
| Prostate cancer and cancer other than breast and prostate | 69 (33.5) | 23 (63.9) | 46 (27.1) | ||
| Two cancers other than breast and prostate | 1 (0.5) | 1 (2.8) | 0 | ||
| Cases with 3 cancer diagnoses | 26 (1.9) | 2 (0.4) | 24 (2.6) | 19.60 (4.64-82.89) | <.001 |
| Bilateral breast and prostate cancer | 5 (19.2) | 0 | 5 (20.8) | ||
| Bilateral breast and cancer other than breast and prostate | 7 (26.9) | 0 | 7 (29.2) | ||
| Prostate cancer and 2 cancers other than breast and prostate | 1 (3.8) | 1 (50.0) | 0 | ||
| Breast, prostate, and cancer other than breast and prostate | 13 (50.0) | 1 (50.0) | 12 (50.0) | ||
Abbreviation: CIMBA, Consortium of Investigators of Modifiers of BRCA1/2.
a
Analyses adjusted for age at cancer diagnosis/last follow-up, country of origin, and calendar year of interview.