Table 2. Age at First Cancer Diagnosis According to Cancer Site and BRCA1/2 Pathogenic Variant (PV) Status in the 1376 Affected Male Carriers Within CIMBA Data Set.
| Cancer diagnosis | Total carriers | BRCA1 PV carriers | BRCA2 PV carriers | P valuea | |||
|---|---|---|---|---|---|---|---|
| No. (%) | Age at diagnosis, median (IQR) | No. (%) | Age at diagnosis, median (IQR) | No. (%) | Age at diagnosis, median (IQR) | ||
| Male breast cancer | 485 (35.3) | 61.5 (16.0) | 57 (12.5) | 61.0 (20.0) | 428 (46.4) | 61.5 (15.3) | .87 |
| Prostate cancer | 337 (24.5) | 63.2 (12.5) | 101 (22.3) | 65.0 (12.0) | 236 (25.6) | 63.1 (12.2) | .09 |
| Cancers other than breast and prostate | 554 (40.2) | 59.2 (19.6) | 296 (65.2) | 61.8 (20.0) | 258 (28.0) | 56.5 (20.3) | .003 |
Abbreviations: CIMBA, Consortium of Investigators of Modifiers of BRCA1/2; IQR, interquartile range.
a
Mann-Whitney test for the comparison of median age at first cancer diagnosis between male BRCA1 and BRCA2 PV carriers.