Table I.
Clinical, hematologic, and angiographic characteristics of population with acute coronary syndrome according to platelet-to-lymphocyte ratio tertiles
| Variables | PLR | P-value | ||
|---|---|---|---|---|
| Tertile 183.7 ±14.5 (n = 180) |
Tertile 2125.2 ±13.2 (n = 179) |
Tertile 3203.3 ±43.7 (n = 179) |
||
| Age [years] | 59.2 ±12.3 | 61.4 ±12.5 | 63.9 ±13.7 | 0.003a |
| Male gender, n (%) | 131 (72.8) | 123 (68.7) | 120 (67) | 0.478 |
| Hypertension, n (%) | 78 (43.3) | 74 (41.3) | 93 (52.0) | 0.100 |
| Diabetes mellitus, n (%) | 37 (20.6) | 48 (26.8) | 53 (29.6) | 0.132 |
| Smoking, n (%) | 82 (45.6) | 75 (41.9) | 69 (38.5) | 0.404 |
| Previous MI history, n (%) | 22 (12.2) | 32 (17.9) | 23 (12.8) | 0.246 |
| Hemoglobin [g/dl] | 14.1 ±1.4 | 13.9 ±1.6 | 13.6 ±1.7 | 0.015b |
| White blood cell count [103/μl] | 11.6 ±3.3 | 11.4 ±3.5 | 11.8 ±3.7 | 0.547 |
| Neutrophil count [103/μl] | 7.8 ±3.1 | 8.5 ±3.3 | 9.6 ±3.6 | < 0.001c |
| Lymphocyte count [103/μl] | 2.8 ±0.8 | 2.1 ±0.5 | 1.5 ±0.5 | < 0.001d |
| Platelet count [103/μl] | 228.1 ±53.9 | 253.7 ±52.5 | 285.2 ±65.6 | < 0.001e |
| Creatinine [mg/dl] | 0.80 (0.72–0.97) | 0.80 (0.70–0.96) | 0.83 (0.72–1.00) | 0.449 |
| CRP [mg/dl] | 0.52 (0.30–0.97) | 0.59 (0.34–0.99) | 0.63 (0.38–1.13) | 0.452 |
| Total cholesterol [mg/dl] | 177.6 ±39.7 | 181.9 ±44.8 | 174.5 ±37.9 | 0.226 |
| Triglyceride [mg/dl] | 135 (90–205) | 135 (92–195) | 120 (80–176) | 0.031f |
| LDL [mg/dl] | 109.8 ±31.6 | 113.9 ±37.2 | 111.1 ±31.7 | 0.504 |
| HDL [mg/dl] | 34.5 ±8.2 | 36.3 ±9.7 | 35.4 ±10.0 | 0.179 |
| Left ventricular EF (%) | 50 (45–55) | 48 (40–55) | 45 (40–50) | 0.004g |
| Patients who underwent PCI | 146 (81.1) | 153 (85.5) | 160 (89.4) | 0.086 |
| Patients who underwent CABG | 18 (10) | 25 (14) | 33 (18.4) | 0.072 |
| Number of stenosed coronary arteries, n (%): | 0.914 | |||
| Single vessel | 75 (41.7) | 77 (43.0) | 73 (40.8) | |
| Two vessels | 61 (33.9) | 53 (29.6) | 58 (32.4) | |
| Three vessels | 44 (24.4) | 49 (27.4) | 48 (26.8) | |
| Type of acute coronary syndrome, n (%): | 0.002 | |||
| USAP | 24 (13.3) | 16 (8.9) | 19 (10.6) | |
| NSTEMI | 65 (36.1) | 53 (29.6) | 34 (19.0) | |
| STEMI | 91 (50.6) | 110 (61.5) | 126 (70.4) | |
| Culprit vessel, n (%): | 0.585 | |||
| LAD | 75 (41.7) | 82 (45.8) | 84 (46.9) | |
| Cx | 52 (28.9) | 51 (28.5) | 41 (22.9) | |
| RCA | 53 (29.4) | 46 (25.7) | 54 (30.2) | |
| Long-term mortality, n (%): | ||||
| 1 year | 11 (6.1) | 21 (11.7) | 35 (19.6) | 0.001 |
| 3 years | 18 (10.0) | 29 (16.2) | 50 (27.9) | < 0.001 |
| 5 years | 27 (15.0) | 34 (19.0) | 55 (30.7) | 0.001 |
Data are presented as number (percentage) and mean ± standard deviation or median (interquartile range) values. For post hoc analysis either Scheffe or Mann-Whitney U test was performed. *ANOVA and Kruskal-Wallis tests:
1 vs. 2, 1 vs. 3, and 2 vs. 3 p = 0.254, p = 0.003, and p = 0.192, respectively
1 vs. 2, 1 vs. 3, and 2 vs. 3 p = 0.567, p = 0.017, and p = 0.197, respectively
1 vs. 2, 1 vs. 3, and 2 vs. 3 p = 0.143, p < 0.001, and p = 0.010, respectively
1 vs. 2, 1 vs. 3, and 2 vs. 3 p < 0.001, p < 0.001, and p < 0.001, respectively
1 vs. 2, 1 vs. 3, and 2 vs. 3 p < 0.001, p < 0.001, and p < 0.001, respectively
1 vs. 2, 1 vs. 3, and 2 vs. 3 p = 0.788, p = 0.026, and p = 0.020, respectively
1 vs. 2, 1 vs. 3, and 2 vs. 3 p = 0.091, p = 0.001, and p = 0.162, respectively.
CRP – C-reactive protein, Cx – circumflex, EF – ejection fraction, HDL – high-density lipoprotein, LAD – left anterior descending, LDL – low-density lipoprotein, MI – myocardial infarction, NLR – neutrophil-to-lymphocyte ratio, NSTEMI – non-ST-segment elevation myocardial infarction, PLR – platelet-to-lymphocyte ratio, RCA – right coronary artery, STEMI – ST-segment elevation myocardial infarction, USAP – unstable angina pectoris. CRP values were available for 225 patients.