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. 2020 Jun 26;8:636. doi: 10.3389/fbioe.2020.00636

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Copyright © 2020 Xu, Yuan, Lin, Ye, Fan, Zhang, Yang, Jiang, Jiang, Wang and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MSCs from three sources at day 14 post orthotopic injection into pancreatic parenchyma of SD rats. (A) Representative fluorescence micrographs of cryo-sections in the EnSCs (upper panel), DPSCs (middle panel) and ADSCs (bottom panel) engraftment groups 14 days after orthotopical transplantation into pancreatic parenchyma of SD rats, respectively. DiI fluorescence, red; DAPI fluorescence, blue. Scale bar = 20 μm. (B) The average ratios of Matrigel-based CM-DiI-labeled cells counted in the pancreatic cryo-sections. Shown in the histogram were the percentages of Matrigel-based CM-DiI-labeled MSCs in the three groups compared to the total nuclei. *p < 0.05. (C) Blood glucose levels in SD rats transplanted orthotopically with Matrigel-based hEnSCs, Matrigel-based hDPSCs, and Matrigel-based hADSCs. Shown are the average blood glucose levels of the tail tip measured and plotted for each time point.