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. 2020 Jul 3;20:43. doi: 10.1186/s40644-020-00323-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — MRI texture feature of difference entropy found to be a significant predictor of TTR on univariable analysis. Top row (a, b): 54-year-old female with moderately differentiated ICC in segment 4 (AJCC stage 1). T1-weighted post-contrast MR image obtained during portal venous phase (a, arrow) with an overlying difference entropy texture map (b, arrow). This patient’s ICC difference entropy parameter was calculated to be 2.16 (scale 0–3, blue-red), with corresponding TTR of 825 days. Bottom row (c, d): 56-year-old female with poorly differentiated ICC (AJCC stage 3) in segment 4/8 on T1-weighted post-contrast MR image obtained during portal venous phase (c, arrow) and with an overlying difference entropy texture map (d, arrow). This patient’s ICC difference entropy parameter was calculated to be 1.22 (scale 0–3, blue-red) with corresponding TTR of 456 days. Color scale bar is shown on the right