Table 4.
Results from logistic regression analysis of qualitative imaging features as predictors of pathologic grade and AJCC tumor stage. AUC, odds ratio (OR) and 95% confidence interval for the OR for the effect of each CT and MRI qualitative imaging feature derived by each observer on each binary outcome are shown
| Observer 1 | Observer 2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Outcome | Modality | Feature | AUC | OR | 95% CI | P | AUC | OR | 95% CI | P |
| Tumor Grade (G2 vs. G3) | CT | Biliary Obstruction | 0.50 | 0.99 | 0.32–3.01 | 0.982 | 0.59 | 2.02 | 0.64–6.33 | 0.228 |
| Capsular Retraction | 0.63 | 0.33 | 0.10–1.09 | 0.068 | 0.63 | 0.31 | 0.09–1.06 | 0.061 | ||
| Enhancement Pattern | 0.57 | 5.00 | 0.54–46.34 | 0.157 | 0.55 | 2.39 | 0.4213.67 | 0.329 | ||
| Satellite Lesions | 0.58 | 2.37 | 0.62–9.09 | 0.207 | 0.54 | 1.66 | 0.42–6.61 | 0.470 | ||
| Vascular involvement | 0.53 | 0.79 | 0.24–2.60 | 0.697 | 0.53 | 0.76 | 0.25–2.38 | 0.643 | ||
| MRI | DWI Appearance | 0.58 | 0.50 | 0.07–3.55 | 0.488 | 0.53 | 0.75 | 0.11–5.24 | 0.772 | |
| Biliary Obstruction | 0.68 | 5.00 | 1.15–21.80 | 0.032 | 0.65 | 3.94 | 0.91–17.01 | 0.066 | ||
| Capsular Retraction | 0.60 | 2.25 | 0.57–8.82 | 0.245 | 0.52 | 0.75 | 0.14–3.98 | 0.736 | ||
| Enhancement Pattern | 0.53 | 1.54 | 0.29–8.18 | 0.613 | 0.50 | 1.07 | 0.18–6.22 | 0.939 | ||
| Hepatobiliary Phase | 0.55 | 0.64 | 0.15–2.72 | 0.546 | 0.57 | 0.55 | 0.13–2.26 | 0.406 | ||
| Satellite Lesions | 0.53 | 1.54 | 0.29–8.18 | 0.613 | 0.53 | 1.71 | 0.25–11.78 | 0.584 | ||
| Vascular involvement | 0.51 | 1.09 | 0.27–4.41 | 0.903 | 0.54 | 1.46 | 0.32–6.70 | 0.628 | ||
| AJCC Stage (Stage I-II vs stage III) | CT | Biliary Obstruction | 0.70 | 5.38 | 1.61–17.97 | 0.006 | 0.73 | 7.18 | 2.10–24.57 | 0.002 |
| Capsular Retraction | 0.53 | 0.79 | 0.26–2.42 | 0.686 | 0.56 | 0.58 | 0.17–1.91 | 0.368 | ||
| Enhancement Pattern | 0.59 | 7.78 | 0.84–72.11 | 0.071 | 0.57 | 3.75 | 0.65–21.46 | 0.138 | ||
| Satellite Lesions | 0.65 | 4.81 | 1.26–18.35 | 0.022 | 0.60 | 3.33 | 0.86–12.99 | 0.083 | ||
| Vascular involvement | 0.64 | 3.51 | 1.04–11.84 | 0.043 | 0.68 | 4.89 | 1.48–16.13 | 0.009 | ||
| MRI | DWI Appearance | 0.56 | 1.67 | 0.21–13.22 | 0.629 | 0.70 | 5.33 | 0.62–45.99 | 0.128 | |
| Biliary Obstruction | 0.66 | 3.86 | 0.94–15.86 | 0.061 | 0.66 | 3.86 | 0.94–15.86 | 0.061 | ||
| Capsular Retraction | 0.56 | 0.60 | 0.16–2.29 | 0.455 | 0.56 | 0.43 | 0.07–2.58 | 0.355 | ||
| Enhancement Pattern | 0.55 | 1.89 | 0.36–10.03 | 0.455 | 0.58 | 3.00 | 0.47–19.04 | 0.244 | ||
| Hepatobiliary Phase | 0.66 | 5.32 | 0.94–29.99 | 0.058 | 0.63 | 3.55 | 0.76–16.43 | 0.106 | ||
| Satellite Lesions | 0.61 | 4.09 | 0.67–24.83 | 0.126 | 0.60 | 6.33 | 0.63–63.64 | 0.117 | ||
| Vascular involvement | 0.63 | 3.00 | 0.73–12.27 | 0.126 | 0.73 | 19.00 | 2.03–177.93 | 0.010 | ||
Footnote: Pathologic tumor grade was defined as follows: G2: moderately differentiated, G3: poorly differentiated
Significant results are bolded