Table 6.
Association of quantitative imaging features for CT and MRI with time to recurrence (TTR) and overall survival (OS) in patients with ICC. The hazard ratios (HR) and lower and upper limits of a 95% confidence interval from Cox regression are shown, when available
| Feature | TTR | OS | |||||||
|---|---|---|---|---|---|---|---|---|---|
| p* | p** | HR | 95% CI | p* | p** | HR | 95% CI | ||
| CT | Energy | 0.096 | 0.065 | 0.51 | 0.23–1.15 | 0.345 | 0.293 | 0.65 | 0.27–1.59 |
| Contrast | 0.713 | 0.980 | 1.06 | 0.77–1.46 | 0.305 | 0.278 | 1.21 | 0.84–1.74 | |
| Correlation | 0.864 | 0.875 | 0.97 | 0.71–1.34 | 0.367 | 0.335 | 0.85 | 0.59–1.22 | |
| Variance | 0.208 | 0.185 | 0.83 | 0.63–1.11 | 0.184 | 0.243 | 0.80 | 0.58–1.11 | |
| Homogeneity | 0.404 | 0.496 | 0.87 | 0.62–1.22 | 0.385 | 0.378 | 0.83 | 0.54–1.27 | |
| Sum Average | 0.045 | 0.021 | 0.70 | 0.49–0.99 | 0.147 | 0.132 | 0.72 | 0.46–1.12 | |
| Sum Variance | 0.124 | 0.126 | 0.79 | 0.58–1.07 | 0.136 | 0.100 | 0.76 | 0.53–1.09 | |
| Sum Entropy | 0.153 | 0.089 | 1.43 | 0.88–2.33 | 0.551 | 0.567 | 1.19 | 0.68–2.06 | |
| Entropy | 0.038 | 0.042 | 1.59 | 1.03–2.45 | 0.292 | 0.247 | 1.32 | 0.79–2.21 | |
| Difference Variance | 0.713 | 0.980 | 1.06 | 0.77–1.46 | 0.305 | 0.278 | 1.21 | 0.84–1.74 | |
| Difference Entropy | 0.387 | 0.527 | 1.15 | 0.83–1.60 | 0.304 | 0.292 | 1.23 | 0.83–1.83 | |
| Information Measure of Correlation 1 | 0.064 | 0.075 | 1.49 | 0.98–2.28 | 0.421 | 0.331 | 1.23 | 0.75–2.02 | |
| Information Measure of Correlation 2 | 0.047 | 0.132 | 0.73 | 0.53–1.00 | 0.187 | 0.209 | 0.78 | 0.54–1.13 | |
| Maximal Correlation Coefficient | 0.165 | 0.169 | 0.77 | 0.53–1.11 | 0.213 | 0.174 | 0.74 | 0.47–1.18 | |
| Enhancement Ratio (AP) | 0.104 | 0.146 | 0.43 | 0.16–1.2 | 0.361 | 0.320 | 0.63 | 0.23–1.70 | |
| Enhancement Ratio (PVP) | 0.238 | 0.247 | 0.64 | 0.30–1.4 | 0.187 | 0.127 | 0.57 | 0.25–1.30 | |
| MRI | Energy | 0.922 | 0.909 | 1.02 | 0.66–1.59 | 0.520 | 0.543 | 0.73 | 0.29–1.88 |
| Contrast | 0.133 | 0.102 | 0.63 | 0.34–1.15 | 0.097 | 0.101 | 0.48 | 0.20–1.15 | |
| Correlation | 0.129 | 0.097 | 1.58 | 0.88–2.86 | 0.087 | 0.091 | 2.05 | 0.89–4.74 | |
| Variance | 0.601 | 0.641 | 0.89 | 0.58–1.37 | 0.654 | 0.750 | 0.87 | 0.48–1.59 | |
| Homogeneity | 0.011 | 0.006 | 1.79 | 1.13–2.84 | 0.171 | 0.191 | 1.46 | 0.84–2.54 | |
| Sum Average | 0.277 | 0.194 | 0.79 | 0.51–1.22 | 0.703 | 0.766 | 0.90 | 0.52–1.56 | |
| Sum Variance | 0.629 | 0.584 | 0.90 | 0.60–1.37 | 0.838 | 0.877 | 0.94 | 0.54–1.65 | |
| Sum Entropy | 0.240 | 0.192 | 1.43 | 0.78–2.62 | 0.354 | 0.465 | 1.48 | 0.65–3.39 | |
| Entropy | 0.323 | 0.322 | 1.28 | 0.79–2.08 | 0.186 | 0.199 | 1.60 | 0.80–3.22 | |
| Difference Variance | 0.133 | 0.102 | 0.63 | 0.35–1.15 | 0.097 | 0.101 | 0.48 | 0.20–1.15 | |
| Difference Entropy | 0.015 | 0.013 | 0.58 | 0.37–0.91 | 0.140 | 0.154 | 0.67 | 0.38–1.16 | |
| Information Measure of Correlation 1 | 0.420 | 0.524 | 1.21 | 0.76–1.92 | 0.059 | 0.038 | 1.87 | 0.97–3.62 | |
| Information Measure of Correlation 2 | 0.736 | 0.985 | 0.93 | 0.61–1.43 | 0.068 | 0.050 | 0.62 | 0.36–1.05 | |
| Maximal Correlation Coefficient | 0.464 | 0.642 | 1.15 | 0.79–1.65 | 0.621 | 0.586 | 1.15 | 0.67–1.97 | |
| ADCMean | 0.042 | 0.058 | NA | NA | 0.309 | 0.289 | NA | NA | |
| ADCMin | 0.476 | 0.504 | NA | NA | 0.005 | 0.015 | NA | NA | |
| Enhancement Ratio (AP) | 0.040 | 0.024 | 0.34 | 0.12–1.00 | 0.476 | 0.569 | 0.64 | 0.19–2.2 | |
| Enhancement Ratio (EP) | 0.439 | 0.232 | 0.69 | 0.26–1.80 | 0.536 | 0.688 | 0.70 | 0.22–2.2 | |
| Enhancement Ratio (HBP) | 0.117 | 0.119 | NA | NA | 0.522 | 0.495 | NA | NA | |
| Enhancement Ratio (PVP) | 0.069 | 0.058 | 0.42 | 0.17–1.10 | 0.226 | 0.318 | 0.52 | 0.18–1.50 | |
Footnote: *p-values from the log-rank test, **p-values from generalized Wilcoxon tests
Significant results are bolded