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Proposed model for the interaction between SGIV and autophagy. SGIV infection inhibited autophagy initiation, which is mTOR-dependent. The inhibition mechanisms of SGIV include increasing the cytoplasmic p53 level and encoding viral proteins (VP48, VP122, VP132), which bind Atg5 to block the LC3 conversion. From the perspective of the host cell, autophagy pathway decreased SGIV replication.
