Fig. 2.

a Manhattan plot of the meQTL associations in whole-blood samples of 216 adolescents. The line represents the significance level at Bonferroni corrected p value of 0.05. b Blood DNAm levels (β values) at cg02098413 within the HACE1 gene in the discovery cohort. Adolescents with depression DAWBA band risk scores below 15% were defined as “Low-risk”, while individuals with depression DAWBA level bands 3 (≈ 15%), 4 (≈ 50%), or 5 (> 70%) were assigned to the “High-risk” category. c Blood DNAm levels (β values) at cg02098413 within HACE1 gene vs the presence of the risk allele (C allele) at rs1933802. *p values < 0.05, **p values < 0.005