Table 2.
Association of genetic models of PIN3 16-bp duplication polymorphism of TP53 with breast cancer risk
| Genotype/Allele | Cases | Controls | OR (95% CI) | P |
|---|---|---|---|---|
| N = 60 | N = 60 | |||
| A1A1 | 27 (45.0) | 39 (65.0) | Reference | |
| A1A2 | 25 (41.7) | 16 (26.7) | 2.25 (1.01–5.01) | 0.04 |
| A2A2 | 8 (13.3) | 5 (8.3) | 2.31 (0.68–7.83) | 0.17 |
| A2A2 + A1A2 | 33 (55.0) | 21 (35.0) | 2.26 (1.08–4.73) | 0.02 |
| A1A1 + A1A2 | 52 (86.7) | 55 (91.7) | Reference | |
| A2A2 | 8 (13.3) | 5 (8.3) | 1.69 (0.52–5.50) | 0.38 |
| A1 | 79 (65.8) | 94 (78.3) | Reference | |
| A2 | 41 (34.2) | 26 (21.7) | 1.87 (1.05–3.33) | 0.03 |
N Number, CI confidence Interval, P p-value, A2A2 + A1A2 vs. A1A1: Dominant model, A2A2 vs. A1A1 + A1A2: Recessive model; A2 vs. A1: Additive model.