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. 2020 Jul 2;27(2):1073274820936287. doi: 10.1177/1073274820936287

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© The Author(s) 2020

This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — Distribution-based cutoff optimization of biologically effective dose (BED) in patients with brain metastasis (BM) from small-cell lung cancer (SCLC). A, Receiver operating characteristic curve for BED. Biologically effective dose value was used as a negative marker for the event of death. A BED score of 47.4 was chosen as the cutoff point representing the optimal balance between sensitivity (50%) and specificity (77.3%). Area under the curve = 0.62. B, Waterfall plot of BED. Biologically effective dose values were stratified with the optimal threshold obtained from (A). C, Plot of the odds ratio with 95% CI for each BED threshold. D, Plot of the hazard ratio with 95% CI for each BED threshold. Vertical lines indicate the data distribution correlated most strongly with overall survival. Dashed lines indicate the 95% CIs. The distribution of BED values among the 250 patients included in this study is shown as a rug plot at the bottom of the figure.