Table 1.
Baseline Characteristics of 250 Patients With Small-Cell Lung Cancer and Brain Metastasis.
| Variables | N | % |
|---|---|---|
| Age (years) | ||
| <60 | 125 | 50 |
| ≥60 | 125 | 50 |
| ECOG score | ||
| 0 | 227 | 90.8 |
| 1 | 19 | 7.6 |
| 2 | 2 | 0.8 |
| 3 | 2 | 0.8 |
| Gender | ||
| Male | 234 | 93.6 |
| Female | 16 | 6.4 |
| Smoking | ||
| Yes | 166 | 66.4 |
| No | 84 | 33.6 |
| Clinical stage | ||
| II | 16 | 6.4 |
| III + IV | 234 | 93.6 |
| Surgery in primary lesion | ||
| Yes | 17 | 6.8 |
| No | 233 | 93.2 |
| Chemotherapy before BM | ||
| Yes | 225 | 90 |
| No | 25 | 10 |
| Chemo cycles | ||
| <10 | 226 | 90.4 |
| ≥10 | 24 | 9.6 |
| Radiotherapy in primary lesion | ||
| Yes | 132 | 47.2 |
| No | 118 | 52.8 |
| BED in brain | ||
| ≤47.4 Gy | 190 | 76 |
| >47.4 Gy | 60 | 24 |
| RFI (months) | ||
| ≤20 | 232 | 92.8 |
| >20 | 18 | 7.2 |
| External metastasis | ||
| Yes | 208 | 83.2 |
| No | 42 | 16.8 |
| Number of external metastasis | ||
| ≤2 | 213 | 85.2 |
| >2 | 37 | 14.8 |
| Maximum diameter of the largest tumor (cm) | ||
| ≤2 | 112 | 44.8 |
| 2-4 | 100 | 40 |
| 4-6 | 25 | 10 |
| ≥6 | 13 | 5.2 |
| Bilateral BM | ||
| Yes | 134 | 53.6 |
| No | 116 | 46.4 |
| Subfalcine herniation | ||
| Yes | 17 | 6.8 |
| No | 233 | 93.2 |
| Number of BMs | ||
| ≤3 | 105 | 42 |
| >3 | 145 | 58 |
| Severe neurological symptom | ||
| Yes | 53 | 78.8 |
| No | 197 | 21.2 |
| Pleural effusion | ||
| Yes | 64 | 25.6 |
| No | 186 | 74.4 |
| GPA | ||
| ≤1.5 | 96 | 38.4 |
| >1.5 | 154 | 61.6 |
Abbreviations: BED, biologically effective dose; BM, brain metastasis; ECOG, Eastern Cooperative Oncology Group; GPA, graded prognostic assessment; RFI, recurrence-free interval.