Table 3.
Cox Regression Analysis of 250 Patients With Small-Cell Lung Cancer and Brain Metastasis.
| Variable | n | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | ||
| Age (years) | |||||||
| <60/≥60 | 125/125 | 0.763 | 0.558-0.990 | .042 | 0.671 | 0.511-0.882 | .004 |
| ECOG score | |||||||
| 0 | 227 | .021 | .042 | ||||
| 1 | 19 | 1.304 | 0.814-2.090 | .270 | 1.415 | 0.849-2.358 | .183 |
| 2 | 2 | 4.860 | 1.184-19.955 | .028 | 4.006 | 0.941-17.053 | .060 |
| 3 | 2 | 4.426 | 1.078-18.173 | .039 | 3.941 | 0.934-16.637 | .062 |
| Gender | |||||||
| Male/female | 234/16 | 1.557 | 0.934-2.597 | .089 | |||
| Smoking | |||||||
| Yes/no | 166/84 | 0.719 | 0.548-0.943 | .017 | 0.739 | 0.559-0.976 | .033 |
| Clinical stage | |||||||
| II/III-IV | 16/234 | 1.607 | 0.931-2.773 | .089 | |||
| Surgery in primary lesion | |||||||
| Yes/no | 17/233 | 0.707 | 0.423-1.181 | .185 | |||
| Chemotherapy before BM | |||||||
| Yes/no | 225/25 | 1.138 | 0.750-1.728 | .542 | |||
| Chemo cycles | |||||||
| <10/≥10 | 226/24 | 0.995 | 0.628-1.576 | .983 | |||
| Radiotherapy in primary lesion | |||||||
| Yes/no | 132/118 | 0.790 | 0.608-1.027 | .078 | |||
| BED in brain | |||||||
| ≤47.4 Gy/ >47.4 Gy | 190/60 | 0.478 | 0.346-0.660 | <.001 | 0.383 | 0.261-0.564 | <.001 |
| RFI (months) | |||||||
| ≤20/>20 | 18/232 | 1.161 | 0.872-1.547 | .307 | |||
| External metastasis | |||||||
| Yes/no | 208/42 | 1.301 | 1.004-1.686 | .047 | |||
| Number of external metastasis | |||||||
| ≤2/>2 | 213/37 | 1.209 | 0.846-1.726 | .298 | |||
| Maximum diameter of the largest tumor (cm) | |||||||
| <2 | 112 | .164 | |||||
| 2-4 | 100 | 1.181 | 0.890-1.566 | .249 | |||
| 4-6 | 25 | 0.674 | 0.411-1.103 | .116 | |||
| >6 | 13 | 1.012 | 0.566-1.811 | .968 | |||
| Bilateral BM | |||||||
| Yes/no | 134/116 | 1.081 | 0.833-1.403 | .557 | |||
| Subfalcine herniation | |||||||
| Yes/no | 17/233 | 1.039 | 0.633-1.707 | .879 | |||
| Number of BMs | |||||||
| ≤3/>3 | 105/145 | 1.322 | 1.015-1.723 | .039 | |||
| Severe neurological symptom | |||||||
| Yes/no | 53/197 | 0.902 | 0.657-1.237 | .522 | |||
| Pleural effusion | |||||||
| Yes/no | 64/186 | 1.192 | 0.877-1.620 | .262 | 1.336 | 0.958-1.862 | .088 |
| GPA | |||||||
| ≤1.5/>1.5 | 96/154 | 0.915 | 0.702-1.192 | .511 | |||
Abbreviations: BED, biologically effective dose; BM, brain metastasis; ECOG, Eastern Cooperative Oncology Group; GPA, graded prognostic assessment; HR, hazard ratio; RFI, recurrence-free interval; SCLC, small-cell lung cancer.
The bold values indicate P-value is less than 0.05.