TABLE 1.
Proposed phenotype data points for infertile males.
| Demographics |
| Age (y) |
| Partner’s age (y) |
| Race/ethnicity |
| Body mass index (kg/m2) |
| Clinical |
| Months of infertility |
| Complete medical history |
| Spermatotoxic medications and exposures |
| Complete phenotyping of female infertility factors |
| Comprehensive familial health history |
| Anatomical |
| Testis longitudinal axis (cm) |
| Presence of varicocele and associated grade |
| Scrotal ultrasound findings |
| Hormones |
| Follicle-stimulating hormone |
| Luteinizing hormone |
| Total, bioavailable, and free testosterone |
| Sex hormone-binding globulin |
| Estradiol |
| Inhibin B |
| Thyroid-stimulating hormone |
| Prolactin |
| Karyotype |
| Y chromosome microdeletion |
| Semen analysisa |
| Volume (mL) |
| Sperm count |
| Sperm concentration (M/mL) |
| % Motility |
| % Progressive motility |
| Total motile count |
| Morphology (% normal) |
| % Head defects |
| % Neck/midpiece defects |
| % Cytoplasmic defects |
| % Tail defects |
a
At least two semen analyses, preferably three.