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. 2020 Jun 26;11:979. doi: 10.3389/fphar.2020.00979

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Copyright © 2020 Wu, Mao, Liu, Huang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ligustilide (LIG) attenuated Ca²⁺ influx and reactive oxygen species (ROS) levels in oxygen-glucose deprivation/reperfusion (OGD/R)-induced hippocampal neurons injury. (A) Effect of ligustilide on OGD/R-stimulated intracellular Ca²⁺ influx. (B) Effect of ligustilide on OGD/R-induced ROS overproduction. Cells were treated with LIG (1, 2, and 4 μM) for 3 h, and then subject to OGD/R. Fluo-3/AM and DCFH-DA were used to measure Ca²⁺ influx and ROS levels. The data are represented as means ± SD for three independent experiments. Each of the experiments was repeated three times. The data are means ± SD. ^## P < 0.01 vs. control group; *P < 0.05, **P < 0.01 vs. group treated with OGD/R.