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. 2020 Jun 26;11:1268. doi: 10.3389/fimmu.2020.01268

Figure 1.

Figure 1

Cntn1−/− animals show hematologic and lymphoid abnormalities prior to expiration. (A) Blood from P16 wild-type and Cntn1−/− animals was analyzed for the indicated chemical paramaters (GLU, glucose; NA+, sodium; K+, potassium; TP, total protein; ALB, albumin; GLOB, globulin; ALP, alkaline phosphatase; ALT, alanine aminotransferase; TBIL, bilirubin; BUN, urea; CA, Calcium). (B) Blood from P16 wild-type and Cntn1−/− animals was analyzed for the indicated cellular paramaters (WBC, white blood cells; RBC, red blood cells; RDWc, RBC distribution width; LYM, lymphocytes; MON, monocytes; GRA, granulocytes). (C) Representative images of spleen, thymus and mesenteric lymph nodes (MLN) harvested from P17 wild-type and Cntn1−/− animals are shown. Graphs show weight of animals, spleens, thymuses, livers, and colon weight/length. (D) Representative images of livers (left) and colons (right) from wild-type (top) and Cntn1−/− (bottom) at 10 × (H&E). White and black scale bars represent 100 μm. Analysis of data by Student's t-test. NS, not significant; *p < 0.05; **p < 0.01, ***p < 0.001; ****p < 0.0001.