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. 2020 Jun 26;11:1268. doi: 10.3389/fimmu.2020.01268

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Copyright © 2020 Veny, Grases, Kucharova, Lin, Nguyen, Huang, Ware, Ranscht and Šedý.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cntn1^−/− animals show thymic atrophy prior to expiration. (A) Representative images of P16 thymuses from wild-type (top) and Cntn1^−/− (bottom) at 4 × (H&E, upper panels; TUNEL, lower panels) or 10 × (H&E, middle panels). White scale bars represent 100 μm. (B) Graphs show thymus cellularity (left), cellularity normalized to organ weight (middle), or TUNEL⁺ cells (right) from individual wild-type and Cntn1^−/− animals. Analysis of aggregated data by Student's t-test. **p < 0.01, ***p < 0.001; ****p < 0.0001.