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. 2020 Jun 26;14:595. doi: 10.3389/fnins.2020.00595

FIGURE 1.

FIGURE 1

A simple overview of the Hippo signaling pathway and YAP. The core components of the Hippo signaling pathway are Mst1/2, LATs1/2, YAP/TAZ, and target genes, which are closely connected, especially YAP. The retention method for YAP is in the nucleus and cytoplasm. In the cytoplasm, YAP/TAZ can blind to some specific proteins (such as the 14-3-3 protein) through direct LATs1/2 phosphorylation and indirect Mst1/2 activation. At the same time, SAV1 and MOB1 are defined as regulatory proteins of Mst1/2 and LATs1/2, respectively. Besides, PP2A can inhibit the Mst1/2–SAV1 complex, while both NF2 and AMOT can regulate the LATs1/2–MOB1 complex. In the nucleus transferred from the cytoplasm, YAP can express a series of target genes through interacting with transcription factors, like TEAD family, Smad, p73, ErbB4, Runx1/2, Pax, and TBX5. Finally, when suffering from certain physiological and pathological damage, YAP will degrade.