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. 2020 Jun 26;10:1035. doi: 10.3389/fonc.2020.01035

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Copyright © 2020 Shen, Chen, Li, Liu, Peng, Chen, Wu, Sferra, Wu, Lin, Cheng, Chu, Shen and Peng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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EBF1 is down-regulated in human colorectal cancer. (A) EBF1 mRNA expression (probe1: 11726800_at; probe2: 11726801_at; probe3: 11726802_a_at) in 14 matched CRC and non-cancerous colorectal tissues from our previously described gene expression profile microarrays (GEO Submission: GSE113513). Each dot represents 1 tissue. (B,C) EBF1 mRNA expression in (B) COAD tissues (n = 279) and normal colon tissues (n = 345), (C) READ tissues (n = 92) and normal rectum colon tissues (n = 318) were analyzed based on that in the TCGA datasets through GEPIA website. (D) EBF1 mRNA expression was determined in 11 pairs of CRC samples using Q-PCR and was normalized to GAPDH. T, colorectal cancer tissues; N, non-cancerous colorectal tissues. *P < 0.05 vs. N.