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. 2020 Jun 26;11:1149. doi: 10.3389/fimmu.2020.01149

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Copyright © 2020 Hou, Yang, Chang, Zhao, Zhou, Dong, Liu, Yang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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S1PR₂-siRNA reduced NLRP3, pro-IL-1β, and pro-IL-18 expression in BMMs. (A) The efficiency of S1PR₁, S1PR₂, and S1PR₃ knockdown by their siRNAs in serum-starved BMMs. (B) Effects of S1PR₁, S1PR₂, and S1PR₃ siRNA on NLRP3, pro-IL-1β, and pro-IL-18 mRNA expression in response to 1 μmol/L S1P for 2 h. (C) Mice received an operation of BDL to induce liver injury, then were anesthetized and sacrificed at 1 or 3 days or at 1 or 2 weeks after BDL operation. The relationship between S1PR₂ and NLRP3, pro-IL-1β, and pro-IL-18 in mouse liver was analyzed by regression analysis. Data are presented as the mean ± SEM. Student's t-test was used in panel (A) and one-way ANOVA was used in panel (B). n = 6 per group. *p < 0.05 vs. control; ^#p < 0.05 vs. S1P treatment alone.