Table 2.

Multivariate analysis of variables associated with chronic (A) and moderate to severe (B) neutropaenia

Variables	Chronic neutropaenia (n=25)	Without neutropaenia (n=779)	Univariate		Multivariate
			OR (95% CI)	P value*	OR (95% CI)	Adjusted p value†
(A) Chronic (>6 months) neutropaenia
Thrombocytopaenia, n (%)	11 (45.8)	102 (13.1)	5.59 (2.44 to 12.8)	<0.0001	3.90 (1.67 to 13.3)	0.02
Lymphopaenia, n (%)	23 (92.0)	373 (47.9)	12.5 (2.92 to 53.3)	<0.0001	7.67 (2.44 to 87.5)	0.0007
Anti-Ro/SSA antibodies, n (%)	16 (66.7)	209 (26.8)	2.94 (1.23 to 6.99)	0.01	3.41 (1.46 to 12.9)	0.02
Oral ulcers, n (%)	10 (40.0)	207 (26.7)	1.82 (0.81 to 4.12)	0.16	1.69 (0.63 to 5.06)	0.56

Variables	Moderate to severe neutropaenia (n=20)	Without neutropaenia (n=779)	Univariate		Multivariate
			OR (95% CI)	P value*	OR (95% CI)	Adjusted p value†
(B) Moderate to severe neutropaenia (<1.0×109/L)
Thrombocytopaenia, n (%)	10 (52.6)	102 (13.1)	7.34 (2.91 to 18.5)	<0.0001	5.50 (2.34 to 22.0)	0.005
Lymphopaenia, n (%)	18 (90.0)	373 (47.9)	9.77 (2.25 to 42.4)	0.0002	5.82 (1.73 to 64.7)	0.002
Oral ulcers, n (%)	10 (50.0)	207 (26.8)	2.73 (1.12 to 6.66)	0.02	2.95 (1.12 to 10.7)	0.04
Anti-Ro/SSA antibodies, n (%)	10 (50.0)	209 (40.5)	1.47 (0.60 to 3.59)	0.40	1.65 (0.58 to 5.50)	0.90

(A) Comparison between patients with chronic neutropaenia (n=25) and without neutropaenia (n=779). Significant variables in multivariate analysis.

(B) Comparison between patients with moderate to severe neutropaenia (n=20) and without neutropaenia (n=779). Significant variables in multivariate analysis.

*Difference between patients with chronic neutropaenia or with moderate to severe neutropaenia and patients without neutropaenia using χ² test for qualitative variables and Mann-Whitney test for quantitative variables.

†Adjustment for multiple testing was performed with the Benjamini and Hochberg method.

–, variable not entered in the multivariate model.