Table 3.
Patient and physician perspectives on MPN‐associated symptoms at baseline
| Overall | Cohen's Kappa coefficient b |
ET at initial diagnosis a |
PV at initial diagnosis a |
MF at initial diagnosis a |
|||||
|---|---|---|---|---|---|---|---|---|---|
|
Patient (N = 884) n (%) |
Physician (N = 884) n (%) |
Patient (N = 373) n (%) |
Physician (N = 373) n (%) |
Patient (N = 301) n (%) |
Physician (N = 301) n (%) |
Patient (N = 169) n (%) |
Physician (N = 169) n (%) |
||
| Fatigue (Weariness, Tiredness) | |||||||||
| N | 870 | 884 | 368 | 373 | 297 | 301 | 166 | 169 | |
| Patients with score > 0 c | 621 (71.4) | 424 (48.0) | 0.483 | 262 (71.2) | 182 (48.8) | 202 (68.0) | 141 (46.8) | 129 (77.7) | 88 (52.1) |
| Missing | 14 | 0 | 5 | 0 | 4 | 0 | 3 | 0 | |
| Filling up quickly when you eat (early satiety) | |||||||||
| N | 874 | 884 | 369 | 373 | 297 | 301 | 167 | 169 | |
| Patients with score > 0 c | 420 (48.1) | 225 (25.5) | 0.527 | 163 (44.2) | 93 (24.9) | 131 (44.1) | 70 (23.3) | 102 (61.1) | 56 (33.1) |
| Missing | 10 | 0 | 4 | 0 | 4 | 0 | 2 | 0 | |
| Abdominal discomfort | |||||||||
| N | 874 | 884 | 367 | 373 | 298 | 301 | 168 | 169 | |
| Patients with score > 0 c | 373 (42.7) | 230 (26.0) | 0.577 | 138 (37.6) | 81 (21.7) | 120 (40.3) | 74 (24.6) | 96 (57.1) | 70 (41.4) |
| Missing | 10 | 0 | 6 | 0 | 3 | 0 | 1 | 0 | |
| Inactivity | |||||||||
| N | 875 | 884 | 369 | 373 | 298 | 301 | 167 | 169 | |
| Patients with score > 0 c | 437 (49.9) | 228 (25.8) | 0.481 | 171 (46.3) | 101 (27.1) | 138 (46.3) | 69 (22.9) | 107 (64.1) | 54 (32.0) |
| Missing | 9 | 0 | 4 | 0 | 3 | 0 | 2 | 0 | |
| Problems with concentration | |||||||||
| N | 876 | 884 | 369 | 373 | 298 | 301 | 168 | 169 | |
| Patients with score > 0 c | 422 (48.2) | 206 (23.3) | 0.469 | 165 (44.7) | 90 (24.1) | 144 (48.3) | 71 (23.6) | 91 (54.2) | 41 (24.3) |
| Missing | 8 | 0 | 4 | 0 | 3 | 0 | 1 | 0 | |
| Night sweats | |||||||||
| N | 876 | 884 | 369 | 373 | 298 | 301 | 168 | 169 | |
| Patients with score > 0 c | 301 (34.4) | 191 (21.6) | 0.648 | 100 (27.1) | 65 (17.4) | 106 (35.6) | 68 (22.6) | 77 (45.8) | 56 (33.1) |
| Missing | 8 | 0 | 4 | 0 | 3 | 0 | 1 | 0 | |
| Itching (pruritus) | |||||||||
| N | 874 | 884 | 368 | 373 | 298 | 301 | 168 | 169 | |
| Patients with score > 0 c | 358 (41.0) | 239 (27.0) | 0.649 | 124 (33.7) | 95 (25.5) | 148 (49.7) | 102 (33.9) | 70 (41.7) | 37 (21.9) |
| Missing | 10 | 0 | 5 | 0 | 3 | 0 | 1 | 0 | |
| Bone pain (diffuse, not joint pain or arthritis) | |||||||||
| N | 872 | 884 | 366 | 373 | 298 | 301 | 168 | 169 | |
| Patients with score > 0 c | 376 (43.1) | 221 (25.0) | 0.582 | 147 (40.2) | 99 (26.5) | 115 (38.6) | 72 (23.9) | 94 (56.0) | 46 (27.2) |
| Missing | 12 | 0 | 7 | 0 | 3 | 0 | 1 | 0 | |
| Fever (>37.8°C) | |||||||||
| N | 874 | 884 | 368 | 373 | 298 | 301 | 168 | 169 | |
| Patients with score > 0 c | 123 (14.1) | 70 (7.9) | 0.560 | 30 (8.2) | 20 (5.4) | 41 (13.8) | 25 (8.3) | 48 (28.6) | 25 (14.8) |
| Missing | 10 | 0 | 5 | 0 | 3 | 0 | 1 | 0 | |
| Unintentional weight loss in the last 6 months | |||||||||
| N | 872 | 884 | 367 | 373 | 297 | 301 | 168 | 169 | |
| Patients with score > 0 c | 276 (31.7) | 164 (18.6) | 0.556 | 82 (22.3) | 46 (12.3) | 94 (31.6) | 62 (20.6) | 88 (52.4) | 53 (31.4) |
| Missing | 12 | 0 | 6 | 0 | 4 | 0 | 1 | 0 | |
Abbreviations: ET, essential thrombocythemia; MF, myelofibrosis; MPN, myeloproliferative neoplasm; PV, polycythemia vera.
Initial diagnosis: diagnosis reported retrospectively at baseline visit; corresponded to the first MPN subtype diagnosed (at diagnosis date). Overall column also includes patients with unclassified MPNs.
Only Cohen's Kappa coefficient for overall sample was calculated.
For physician's column, if a particular MPN disease‐associated symptom was ticked in the case record form, it was counted in “patients with score > 0” row.